Anti-Aging: Japanese scientists to manipulate genes to reverse aging of human cells

Japanese scientists have changed the behavior of some genes and gained a better understanding of aging. They say, for further manipulation of genes accelerate or reverse the effects of aging.

The researchers changed the behavior of the two genes that regulate glycine in the mitochondria of the cell, and to understand the preparation of the amino acid, such as those genes or off pass effect. By carefully controlling amino acid production in cells, the researchers could either accelerate intracellular aging or stop and reverse the aging process.

Accelerate aging, the scientists have to develop typical age influenced significant deficiencies. But reverse aging, they succeeded in the capacity of cellular respiration to restore. Scientists have the production of glycine in a cell line of 97 years stimulated only 10 days, but with the complete renewal of cellular respiration and effectively reverse the age of the cell line.

This method is very different from those recently reported and not on stem cells has been a bit controversial to begin. Previous research has on the accumulation of mutations in mitochondrial DNA concentration leading to a decreased cell efficiency. Sufficient disempowered, cells wither and die. Defects in the mitochondria of the cell, always the intention, lead to DNA damage. DNA damage is directly related to hair and weight loss with age, curvature of the spine, osteoporosis and decreased durability, researchers feel.

However, this research has a completely different approach. Director Jun-Ichi Hayashi of the University of Tsukuba, the researchers believe that some crucial genes on and off as we age. Similar research has recently allowed scientists to maintain production of hemoglobin happens.

The team compared strains of human fibroblast cells from fetuses of 12 and the elderly, 80-97 years old harvested. The scientists found that it provokes no difference in the amount of DNA damage in the middle of that previous theories related to aging. The aging test device is due to the addition or subtraction of chemical structures or proteins, motivated Eric Mack,

"In contrast to this sequence mutations damaging, as in the other, the above assumption of aging, epigenetic changes may be similar to embryonic stem cells is reversed by genetic reprogramming cells in a state again aging"

While the fountain of youth remains a little difficult, the scientists believe they are on the right track, and maybe in the future, a simple dietary supplement can help us to remain forever young.

[Photo credit | Getty Images]